I would think you suck the dust out. You wouldn’t have a very dirty place. CAll a professionsor.service.
Get a professional to do this. They have the equipment and will not get your house dirty.
You can use the tins of compressed air.
What type of vents are you asking about, cental air floor vents, window units, etc..
Central air ..take to register off (they pop off, or screwed) spray with a Clorox solution and rinse with hot h2o, while drying use your vacuum to get as deep as you can into the opening. If really bad contact a professional.
Window units, remove filter, rinse with hot h2o, vacumm dust from the units vents and replace filter.