Best way to get rid of Nandina plants?




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It's not a pesticide. It's a herbicide, and it only runs into the groundwater if it's right next to a source of water.
As far as killing birds, that's what Nandina berries do. They have cyanide in them. When a bird (or any other animal) eats them, the cyanogenic glycosides in the digestive tract produce hydrogen cyanide. Hydrogen cyanide is toxic in as little as two milligrams per kilogram of body weight.
Anyone thinking about planting Nandina or giving it away, please do not! Be aware that Nandina is highly invasive in the Americas and is extremely harmful to birds and wildlife. It's also next to impossible to get rid of, so try not to introduce it to any new areas.