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Hi this is Peggy. I hope you are wanting information about the lettuce you are growing. Hope this is helpful. Lettuce Growing Problems and Solutions - Harvest to Table
Lettuce seed has a germination rate of 99 percent at 77°F; the germination ... Sunken, water-soaked spots appear on lower leaves which turn brown and slimy. ... For heading lettuce–crisphead and Romaine varieties–cut heads as soon as ...
first decide what it is then treat it https://dengarden.com/gardening/Common-Diseases-of-Leafy-Vegetables-Prevention-and-Treatment
If they are brown spots are from lettuce being store in high storage temperatures