How can I get rid of Southern thorny vine, Similax?
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Cut the vine as much as you can and providing there is nothing else around it try Brush B Gone by Ortho
Dig up the roots- which grows very large . we have a burn barrel and we burn the roots.
agree on cutting it back as best you can. See if you can get your hands on a product called Crossbow. It's not cheap but it works on anything that has a woody vine-like invasive plant in it's tracks! Good luck!