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Printed on can be removed with a good vinegar soak and scrub. If it is part of the mold when the glass was poured for the bottle, that would need to sanded off very carefully. Then I would question the integrity of the bottle itself if not done properly.
You maybe able to do so with a sanding belt and water much the way glaziers smooth edges of glass tables tops and mirrors etc
I agree with Naomie, I've been researching this for you but can't really find anything about removing raised glass on glass. Everything is about removing labels and print. Maybe you could create a design that uses the letters as part of the design. Different colors and shapes should partially hide it.
You could put a decorative label over it. Or if you were wanting to paint it, you could use a putty to build up around it then paint over it
You can grind it off with a Drexel but you need to wear gloves and eye protection. Also because it heats up you'll need to spritz the bottle frequently with water.
Thanks, but I want a plain bottle when I'm done - any more ideas?
Grinding or sanding ?