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Hi Ned, using 2x2s when framing out a door (or a wall) should ne different than using 2x4s. I've found 2x2s to be notorious for warping so that's something to consider and they will split like crazy if you're not careful. Here's how to build a wall plus door frame out of 2x4s - simply use 2x2s instead: https://www.acmetools.com/blog/build-a-wall-with-a-door-simple-1-2-3/
Problem is there wouldn't be enough wood for hinges, latch and door stop. Most door jambs are about 4". Thickness of 2x4's and drywall on each side. 2x2's wouldn't be able to carry the weight of a door.
Hi! 2"x 4" is actually the minimum to frame. 2x2's aren't going to give you the frame you need. They aren't expensive to buy. Good luck and stay safe!
We tackled doors in a home recently. The first one took a bit of time but we got it. https://www.finehomebuilding.com/project-guides/framing/frame-a-door-rough-opening
You don't, it wouldn't be safe - doorways are framed in with 2x4s, and then a jack stud second 2x4s to support the header.... https://www.youtube.com/watch?v=4BFD1aWgAig
Here are some ideas: https://www.hometalk.com/search/posts?filter=frame%20a%20door